Effect of Intravenous Lidocaine on the Tolerability of Early Oral Feeding After Laparoscopic Colorectal Surgery

Kangbuk Samsung Hospital77 enrolled

Overview

The purpose of this study is to determine whether intravenous lidocaine increase the tolerability of early oral feeding after laparoscopic colorectal surgery in patients with colorectal cancer. * Degree of nausea/vomiting. * Degree of postoperative pain and opioids requirement. * Time to first flatus, time to first stool, time to tolerance of regular diet, rate of postoperative complications and duration of postoperative hospital stay.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Colorectal Cancer

Interventions

LidocaineDRUG

Lidocaine 1mg/kg(loading dose, just before skin incision) and lidocaine(in normal saline, total 240cc) 1mg/kg/hr with ketorolac 90mg for 24hrs.

Normal salineDRUG

Normal saline 5cc(loading dose, just before skin incision) and normal saline 240cc with ketorolac 90mg for 24hrs.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Elective laparoscopic colorectal surgery for colorectal cancer. * Age \> 18 years. * Informed consent. Exclusion Criteria: * Allergy to local anesthetics. * Severe cardiovascular, hepatic, or renal diseases. * Pregnant or lactating patients. * Emergency surgery. * American Society of Anesthesiologists (ASA) class IV

Locations (1)

Hyung Ook Kim

Seoul, South Korea

Outcomes

Primary Outcomes

Prevalence of postoperative nausea and vomiting.

Intolerance to early postoperative oral feeding is defined as the patient's having either nausea or vomiting, requiring that the patient be non-per oral status.