The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Frederiksberg University Hospital36 enrolled

Overview

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Muscle Strength

Interventions

Experimental knee painOTHER

Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad

Non-painful control injectionsOTHER

Injection of isotonic saline into the infrapatellar fat pad

Eligibility

Sex: ALLMin age: 20 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * aged between 20 to 35 years * healthy * untrained (non-regular exercise participation \[i.e. \< 1 day/week\]) Exclusion Criteria: * symptomatic musculoskeletal diseases * history of traumatic injuries to muscles, tendons or joints of the lower extremity * knee joint pain within a month prior to enrollment

Outcomes

Primary Outcomes

Isokinetic knee muscle strength

Time frame: At baseline and after 8 weeks of exercise

Secondary Outcomes

One-leg chair rise

Time frame: At baseline and after 8 weeks of exercise

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.