Radiation Therapy and Intratumoral Autologous Dendritic Cells in Soft Tissue Sarcomas (STS)

Inclusion Criteria: * Intermediate or High grade (AJCC 7th edition Grade 3 and 4 or Grade 2 and 3 of a 3 tier system) STS as determined by local pathology diagnostic biopsy specimen review * Musculoskeletal tumor in extremities, trunk or chest wall * Primary tumor or isolated locally recurrent tumor greater than 5 cm in diameter as measured by Response Evaluation Criteria In Solid Tumors (RECIST) criteria v1.1 * Clinical Stage T2N0M0 (AJCC 7th edition) * Age ≥18 years at time of consent * Eastern Cooperative Oncology Group (ECOG)/Zubrod performance status of 0 or 1 * Patient's written study specific, Institutional Review Board (IRB) stamped informed consent. * Adequate organ function (measured within a week prior to beginning treatment for Arm B and within 2 weeks of beginning treatment for Arm A): white blood count (WBC) \> 3,000/mm³ and absolute neutrophil count (ANC) \>1500/mm³; Platelets \> 100,000/mm³; Hematocrit \> 25%; Bilirubin \< 2.0 mg/dL; Creatinine \< 2.0 mg/dL, or creatinine clearance \> 60 mL/min * Radiation Oncologist must confirm that a 2-3 cm strip of skin can be spared from RT. Exclusion Criteria: * Retroperitoneal or Head and Neck primary locations * Gastrointestinal stromal tumor (GIST) * Demonstrated metastatic disease * Contraindication to resection * Prior RT if the current tumor is locally recurrent after prior resection * Concurrent treatment with any anticancer agent other than RT as dictated by the protocol * Prior chemotherapy for the pre-surgical treatment of the primary tumor (neoadjuvant chemotherapy)Bleeding/coagulation disorder * Human Immunodeficiency Virus (HIV) infection or other primary immunodeficiency disorder * Ongoing systemic therapy with immunosuppressant drugs (e.g. corticosteroids, azathioprine, cyclosporin, methotrexate) * Steroid therapy within 4 weeks of first DC administration * Any serious ongoing infection * Pregnant or lactating women. Patients in reproductive age must agree to use contraceptive methods for the duration of the study (\*A pregnancy test will be obtained before treatment).