In-home Evaluation of a Noninvasive Open Ventilation System in Patients With Severe Respiratory Insufficiency

Inclusion Criteria: * Adult male and female subjects, 21-80 years of age * Diagnosis of chronic respiratory insufficiency including COPD and interstitial lung disease * Requires use of continuous nasal oxygen of at least 2 lpm * Reports limitation of activity due to fatigue or breathlessness * Fluent in written and spoken English language * Ability to be properly fitted with the Breathe nasal mask * Ability to tolerate and be appropriately titrated on the Breathe ventilator * Ability to communicate self-assessment of dyspnea, comfort, and fatigue * Ability and willingness to participate in the study including walking and other activities of daily living * Ability to provide written informed consent Exclusion Criteria: * Recent history of frequent or severe epistaxis * Symptoms of acute respiratory exacerbation within 48 hours of Study Day 1 * Discharge from the hospital within 30 days of study enrollment * Subjects, who in the opinion of the Investigator, are not suitable candidates for enrollment or who are unlikely to be able to comply with trial requirements * Subjects with conditions that, in the Investigator's opinion, contraindicates study participation