Immunogenicity and Safety of the Hepatitis B Vaccine Hepavax-Gene TF and a Comparator Hepatitis B Vaccine in Newborns

Three types of subject: Neonates whose mothers are positive for both HBsAg and HBeAg Neonates whose mothers are positive for only HBsAg Neonates whose mothers are negative for both HBsAg and HBeAg INCLUSION CRITERIA: * Full-term neonates with gestational age from 37 weeks to 42 weeks; * Apgar scores are no less than 7 at birth; * Neonates with standard body temperature (auxiliary temperature \< 37.1°); * Neonates weighing ≥ 2,500 grams at birth; * Neonates with icteric index within the normal range (physiologic jaundice is permitted); * Informed consent form signed by parent/guardian; * The requirements of the clinical trial protocol can be observed on the basis of the opinion of the investigator. EXCLUSION CRITERIA: * Subject's parent has a history of family diseases such as convulsion and brain diseases; * Mothers have low immunologic function or a history of organ transplantation or hemodialysis; * Subject's parent is allergic to any composition of Hepatitis B vaccine; * A family history of thrombocytopenia, or other disturbance of blood coagulation, which may result in a contraindication for intramuscular injection; * Known immunologic function damage; * Mothers had received gamma globulin or immunoglobulin injection during pregnancy; * Any congenital malformation * Known or suspected to suffer from diseases such as active infection and cardiovascular disease; * Any condition believed by the investigator to have possible impact on trial evaluation.