Dose Exploring and Setting Study for Tolvaptan to Treat Hepatic Cirrhosis With Ascites

Inclusion Criteria: 1. hepatic cirrhosis patients after 7days treatment of loop diuretics and aldosterone antagonist but still with ascites 2. Hospitalized patients or those who can be hospitalized in this trial between observation period and posttherapeutic observation (Visits at clinic will be allowed after day 8); 3. During the observation period (-3 day to -1 day ), subjects whose body weight difference fall within ±1.0 kg range 2 days (day-2 and day -1) prior to initiation of trial drug treatment; 4. Ages: ≥18 and ≤75 years of age; 5. Genders: men or women; 6. Signed the Informed Consent Form. Exclusion Criteria: 1. Patients with the following diseases, complications or symptoms: * Hepatic encephalopathy (Coma scale Note 1) grade 2 or higher); * Malignant ascites; * Uncontrolled spontaneous bacterial peritonitis; * Patients are likely to experience alimentary tract hemorrhage during the trial; * Heart failure (NYHA cardiac function scale Note 2) stages 3 and 4); * Anuria (daily urine volume below 100mL); * Dysuria resulting from urethral stricture, calculus and tumors. 2. Patients with the following medical history: * Alimentary tract hemorrhage within 10 days prior to screening; * Cerebrovascular accident within 1 month prior to screening; * Gout attack within 1 month prior to screening; * Past allergy or hypersensitive reactions to benzodiazepines (e.g. benazepril hydrochloride) 3. Systolic pressure below 90mmHg at screening; 4. Patients with the following abnormalities in laboratory examinations at screening: Serum creatinine exceeds 2.5X upper limits of normal, serum Na+\>145mmol/L (or exceeds upper limits of normal), serum K+\>5.5mmol/L, uric acid\>8.0mg/dL (476μmol/L), Child-pugh scale greater than 12. 5. Patients cannot take drugs orally; 6. Pregnant or breast-feeding patients or women at child-bearing ages without taking acceptable contraceptive measures; 7. Patients received albumin or other blood preparations within 4 days prior to trial drug administration; 8. Patients participated in clinical trials of other drugs within 1 month prior to screening; 9. Patients participated in tolvaptan trials and took tolvaptan previously; 10. Patients are unsuitable to participate in this trial in investigators' opinion.