Effect of Treatment With Metformin in Type 2 Diabetes Patients on Alternative Genes Splicing

Inclusion Criteria: * Type 2 Diabetic patients usually treated with metformin (≥ 1400 mg/day), associated or not to other oral anti-diabetic treatment or. injection treatment * Patients major. * Patients with a social security number * Patients having signed a consent to participate in the study Exclusion Criteria: * Intolerance metformin * Patients with type 1. * Patients on pioglitazone or rosiglitazone * Renal failure by an anomaly of the creatinine clearance (\< 60 mL/min). * Patients pregnant or likely to be.