A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers

Kaohsiung Veterans General Hospital.178 enrolled

Overview

Esomeprazole plus aspirin compared with esomeprazole alone for the treatment of aspirin-related peptic ulcers.

The aims of this study are to compare esomeprazole plus aspirin with esomeprazole alone in the treatment of aspirin-related ulcers. Patients with aspirin-related peptic ulcers are randomized to receive esomeprazole (40 mg/day) plus aspirin (100 mg/day) or esomeprazole (40 mg/day) alone for 8 weeks. Follow-up endoscopy was carried out at the end of the eighth week. The primary end point was the healing of peptic ulcers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

178

Conditions

Peptic Ulcer

Interventions

aspirinDRUG

aspirin, 100 mg, qd x 8 weeks

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aspirin users who have a peptic ulcer confirmed by endoscopy Exclusion Criteria: * serious medical illness (including cardiovascular events within 6 months before endoscopy) * acute gastrointestinal bleeding * a history of gastric or duodenal surgery * allergic to the study drugs * require long-term treatment with non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs), antiplatelet agents, or anticoagulant agents * pregnancy

Locations (3)

Chung-Ho Hospital

Kaohsiung, Taiwan, Taiwan

Kaohsiung Veterans General Hospital

Kaohsiung, Taiwan, Taiwan

Kaohsiung Veterans General Hospital

Kaohsiung City, Taiwan

Outcomes

Primary Outcomes

Number of Participants in Whom Peptic Ulcer Was Healed

Number of participants in whom peptic ulcer was healed at week 8

Time frame: 8 weeks

Secondary Outcomes

Number of Participants Deveoping Peptic Ulcer Bleeding

Number of participants deveoping peptic ulcer bleeding during 8-week study period

Time frame: 8 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.