Cardiac surgery with cardiopulmonary bypass (CPB) and hepatic surgery are major operations, associated with a systemic inflammatory response syndrome. The aim of this study is to assess the effectiveness of clinical scoring systems and inflammatory cytokine levels for predicting systemic inflammation. This correlation might identify peri-operative clinical outcomes, then forecast further systemic inflammation in cardiac and hepatic surgical patients.
Systemic inflammatory response syndrome (SIRS) is commonly found in most major surgery. Early detection of SIRS will lead to early treatment. Serum cytokines levels are reliable markers for SIRS detection but with high cost and inconvenience. Clinical Scoring Systems are commonly used for assessment of patients with SIRS. If they have good correlation with cytokine levels, they might be used to predict peri-operative clinical outcomes.
Study Type
OBSERVATIONAL
Enrollment
20
Queen Sirikit Heart Center of the Northeast, Khon Kaen University
Khon Kaen, Changwat Khon Kaen, Thailand
Correlation of clinical scoring systems and inflammatory cytokine levels
Blood samples were collected sequentially at 0, 0.5, 4, 12, and 24 h after CPB for cytokines \[Interleukin (IL)-6, IL-8, and IL-10\] investigation and leukocyte counts. Clinical scoring systems \[Acute Physiology and Chronic Health Evaluation (APACHE) II, Sequential Organ Failure Assessment (SOFA) and Multi-Organ Dysfunction (MOD)\] were calculated and recorded at each time point. Correlations were assessed.
Time frame: 24 h after CPB
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