This is a prospective, multi-center imaging study expecting to enroll approximately 1350 patients scheduled for clinically-indicated coronary angiography. Following informed consent, patient will undergo baseline coronary intravascular ultrasound (IVUS) imaging and non-invasive ultrasound imaging of their carotid arteries. Following a 2-year follow-up period, patients will undergo repeat coronary IVUS and standard invasive coronary angiography as well as carotid ultrasound examination. Additionally, patients will be contacted by phone on an annual basis for 5 years to collect cardiovascular and cerebrovascular clinical endpoints. Evaluations of plaque burden will be made using invasive and non invasive imaging tools in order to assess correlations between vascular beds, imaging technologies and main cardiovascular events.
CTA and PET Substudy: A subset of patients enrolled into the main CAIN3 study will undergo a CTA. At sites where both CTA and PET imaging modalities exist, patients will be asked to undergo both tests. The CTA and PET scans can be done separately on 2 imaging beds on different days or performed on the same imaging bed, resulting in a combined CTA and PET scan being done in one scheduled visit. All imaging will be done within 90 days after the follow up IVUS. The choice of radiotracer used (NaF or FDG) for PET imaging will be dependent upon site and availability on the day of the scan. A total of 120 patients will be enrolled in this substudy with approximately 50-60 undergoing CTA and PET.
Study Type
OBSERVATIONAL
Enrollment
1,626
Royal Alexandra Hospital
Edmonton, Alberta, Canada
University of Alberta Hospital
Edmonton, Alberta, Canada
Foothills Medical Centre
Calgary, British Columbia, Canada
Royal Columbian Hospital
New Westminster, British Columbia, Canada
Vancouver General Hospital
Vancouver, British Columbia, Canada
co-primary outcome measure - Nominal change from baseline in percent atheroma volume
intravascular ultrasound measure
Time frame: 2 years
co-primary outcome measure - nominal change from baseline in carotid IMT
2D B-mode carotid ultrasound measure
Time frame: 2 years
cardiovascular morbidity and mortality
as adjudicated by a Clinical Endpoint Committee
Time frame: 5 years
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Interventional Cardiology Research, St. Paul's Hospital
Vancouver, British Columbia, Canada
Victoria Heart Institute Foundation
Victoria, British Columbia, Canada
John Health Science Center
St. John's, Newfoundland and Labrador, Canada
Queen Elizabeth II - Health Sciences Centre
Halifax, Nova Scotia, Canada
Cambridge Cardiac Care
Cambridge, Ontario, Canada
...and 29 more locations