Preoperative Feeding With a Whey Protein Plus Carbohydrate Drink on the Acute Phase Response and Insulin Resistance

Federal University of Mato Grosso20 enrolled

Overview

Prolonged fasting may increase the organic response to trauma. Carbohydrate-based drinks have been tested and they may reduce insulin resistance. No study so far has aimed to examine the possible benefits of whey protein drink in the composition of preoperative drinks.

The patients will be randomized into two groups: the carbohydrate-protein group (CHO-P) and the control group (CO). The patients will reeive a specific drink to their group on the evening prior to surgery and three hours before the operation. The CHO-P group will receive 474 ml (evening drink) or 237 ml (3h prior to operation drink) of a solution containing 14% whey protein (100% lactoalbumin), 86% carbohydrates (45% hydrolyzed corn starch and 55% sucrose) and 0% lipids (Resource® Breeze - Nestlé, São Paulo, Brasil) and the CO group will receive the same volume of water. Outcome measures On the day of the surgery and on the first postoperative day blood samples will be collected for glucose, insulin, triglycerides, albumin, pre-albumin, CRP, and α-1-acid glycoprotein (α-1-GA) assays. HOMA-IR will be calculated

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Acute Phase Response Insulin Resistance

Interventions

whey protein plus carbohydrate drinkDIETARY_SUPPLEMENT

The CHO-P group received 474 ml (evening drink) or 237 ml (3h prior to operation drink) of a solution containing 14% whey protein (100% lactoalbumin), 86% carbohydrates (45% hydrolyzed corn starch and 55% sucrose) and 0% lipids (Resource® Breeze - Nestlé, São Paulo, Brasil)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults (18-65 years-old) * Both sexes * Candidates to elective moderate operations such as open cholecystectomy, laparoscopic cholecystectomy and unilateral repair of inguinal hernia). Exclusion Criteria: * Acute cholecystitis * Diabetes mellitus * Chronic kidney failure * Chronic liver disease ot serum bilirubin greater than 2 mg/dL, body mass index (BMI) above 35Kg/m2 * American Anesthesiologists Association (ASA) score above 2 * Gastro-esophageal reflux * Gastroparesis or intestinal obstruction * Patients with any non-compliance with the study protocol, or who had associated operations, or presented significant intraoperative occurrences, or experienced prolonged operations (lasting more than 3 hours) were also excluded.

Locations (1)

Hospital Julio Muller

Cuiabá, Mato Grosso, Brazil

Outcomes

Primary Outcomes

insulin resistance

Insulin resistance will be assessed by Homa-IR

Time frame: Homa-IR will be assessed in two time points: baseline (2-3 h before operatio) and 24h after operation

Secondary Outcomes

acute-phase response

Assays for albumin, pre-albumin, C reactive protein and α-1-acid glycoprotein

Time frame: Assays for the various acute-phase proteins will be done 2-3h before operation and 24 h after the operation

Data from ClinicalTrials.gov

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