Outcomes of IVF/ICSI cycles of women with PCOS undergoing Gonadotropin Releasing Hormone (GnRH) agonist and GnRH Antagonist fixed protocol.
Women with PCOS undergoing IVF/ICSI cycles will be evaluated by two different protocols. One arm of the study includes oral contraceptive plus GnRH agonist protocol with 150 IU FSH (standard dose) and second arm includes oral contraceptive plus GnRH Antagonist with 150 IU FSH dose and fixed 6th day starting of GnRH Antagonist.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Enrollment
300
150 IU FSH dose and OCP plus GnRH Agonist (long luteal) IVF/ICSI cycle and 150 IU FSH dose and OCP plus GnRH Antagonist (Fixed protocol) IVF/ICSI Cycle
GnRH Antagonist cycle; 150 IU FSH and sixth day Antagonist will be administered
Bulent Haydardedeoglu
Adana, Turkey (Türkiye)
Ongoing pregnancy rates
Ongoing pregnancy rates measured in OCP plus GnRH Agonist and OCP plus GnRH Antagonist cycles in women with PCOS
Time frame: March 2009 to June 2011
clinical pregnancy rate
To evaluate the clinical pregnancy rates of both study arms
Time frame: from march 2009 to july 2011
Total gonadotropin use
Total gonadotropin use of both study arms
Time frame: From march 2009 to June 2011
OHSS rates
OHSS rates in both study groups
Time frame: from march 2009 to july 2011
Total ongoing pregnancy rate
Total ongoing pregnacy rates of per protocol group including freezing-thawing embryo transfer cycles.
Time frame: from march 2009 to june 2011
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