This study is planned to investigate the relationship between duration of extracorporeal circulation and the extent of (acquired) platelet dysfunctions in patients undergoing cardiac surgery.
Patients undergoing complex cardiac surgery are planned to be included. At several intra- and postoperative measuring point, blood is drawn for multiple electrode aggregometry to investigate ex-vivo platelet aggregation as a surrogate for platelet function. Transfusion rate of allogenic blood products as well as postoperative blood loss is planned to be recorded.
Study Type
OBSERVATIONAL
Enrollment
25
ex vivo platelet aggregation at several intraoperative and postoperative measuring points.
Goethe - University
Frankfurt am Main, Hesse, Germany
Changes in arachidonic acid induced platelet aggregation as compared to baseline (before extracorporeal circulation)
Multiple Electrode aggregometry parameters
Time frame: Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU
Changes in Adenosin Diphosphate (ADP) and Thrombin induced platelet aggregation as compared to baseline (before extracorporeal circulation)
Multiple electrode aggregometry analyses
Time frame: Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU
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