Effects of Administration of Fostamatinib on Blood Concentrations of Digoxin in Healthy Subjects

Inclusion Criteria: * Provision of informed consent prior to any study specific procedures * Male or female subjects aged 18 to 45 years (inclusive) * Minimum weight of 50 kg and body mass index (BMI) between 18 and 30 kg/m2 (inclusive) * Female subjects must have a negative pregnancy test at screening and on Day -1,must not be lactating, and must be of non-childbearing potential Exclusion Criteria: * History or presence of gastrointestinal, hepatic, or renal disease or any other condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs (except for cholecystectomy) * Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of the investigational product * Subjects who smoke more than 5 cigarettes or the equivalent in tobacco per day * Absolute neutrophil count of \<2500/mm3 or 2.5 x 109/L * Previous treatment with fostamatinib or digoxin in the present study