A Single Center Randomized Controlled Trial Assessing Pain and Quality of Life Following Surgery

Inclusion Criteria: * Biopsy proven diagnosis or clinical diagnosis of any benign oral cavity lesion. Pre-surgical biopsy will not be required if lesion is suspected to be benign. * Biopsy proven diagnosis or clinical diagnosis of premalignant oral cavity lesions (leukoplakia, erythroplakia, lichen planus, dysplasia)Pre-surgical biopsy will not be required if lesion is suspected to be benign. * Biopsy proven diagnosis of small superficial oral cavity SCC (stage T1N0) requiring resection without the need for neck dissection. * All pathology will be reviewed at MSK to confirm diagnosis. * The lesion plus the resection margin should not exceed 4.0 cm circumferentially. * Planned to undergo surgical treatment by resection without flap reconstruction and without neck dissection. * All patients age 18 years of age and older. * Karnofsky performance score over 60. Patients on blood thinners (aspirin or Coumadin) will be asked to stop medications 7 days prior to surgery. In the case of Coumadin, patients are switched to lovenox 7 days prior to surgery and this is stopped the day before surgery. Following surgery aspirin or Coumadin are recommenced 48 hours postop. Exclusion Criteria: * Patients with previous Head and Neck radiation * Pregnant or lactating female patients. * Patients with oral cavity squamous cell cancer requiring neck dissection