The purpose of this study is to evaluate the Pharmacokinetic drug interaction and safety of S-amlodipine between free combination of S-amlodipine and Telmisartan and S-amlodipine monotherapy.
Inclusion Criteria:
* Between 20 aged and 50 aged in healthy males
* Weight more than 55kg, BMI 19kg/m2-26kg/m2 at the period of screening
* 100mmHg ≤ sit SBP \< 140mmHg and 60mmHg ≤ sit DBP \< 90mmHg and 50 per/min ≤ Pulse rate \< 95 per/min
* AST, ALT, Total bilirubin \< UNL x 1.5
* Signed the informed consent from prior to the study participation
Exclusion Criteria:
* Have history of significant hepatic, renal, gastrointestinal, pulmonary, musculoskeletal, endocrine, neuropsychiatric, hematologic, cardiovascular diseases
* Have a gastrointestinal disease(ex : Crohn's disease, gastrointestinal ulcer) or surgery(except for Appendectomy, Hernia repair) affected by the absorption of medications
* galactose intolerance or Lapp lactase deficiency or glucose-galactose malabsorption
* Hypersensitivity reactions to drugs or clinically significant hypersensitivity reactions in the history of telmisartan or Amlodipine
* drug abuse, or have a history of drug abuse showed a positive for the Triage TOX drug on urine : amphetamine, barbiturate, cocaine, opiates, benzodiazepines, THC(cannabinoids), methadone etc.
* Subject who takes herbal medicine within 30 days, ethical drug within 14 days, OTC within 7 days before the beginning of study treatment
* unusual diet affected by the absorption, distribution, metabolism, excretion of medications
* Subject who treated with any investigational drugs within 90 days before the beginning of study treatment
* Previously donate whole blood within 60 days or component blood within 30 days or transfusion within 30 days
* Subject who takes inhibitors and inducers of drug metabolizing enzyme(Barbiturates etc.) within 30 days
* A heavy caffeine consumer (caffeine \> 5 units/day)
* A heavy alcohol consumer (alcohol \> 21 units/week, 1 unit=pure alcohol 10mL) or cannot stop drinking
* A heavy smoker (cigarette \> 20 cigarettes per day)
* Positive for Hepatitis B, Hepatitis C, HIV or syphilis
* An impossible one who participates in clinical trial by investigator's decision including laboratory test result, EKG result