Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine

Inclusion Criteria: * Man or woman 18 to 65 years of age. * Meets diagnostic criteria criteria of International Headache Society (IHS) 2004 (2) for migraine with and / or without aura. * Frequency from 2 to 8 migraine attacks per month * Top of crisis over a year and age of onset less than 50 years of age. * Patients want to participate in the study, and able to give informed consent. * If women, the patient must be willing to use an acceptable method of birth control (eg, a hormonal contraceptive, intrauterine device, diaphragm with spermicide or condom with spermicide, or refer abstinence). * Patient able and willing to remain on their medications throughout the study. * Accept the guidelines of the study by filling out the diary and clinical scales. Exclusion Criteria: * Any medical condition that places the patient at risk with its exposure to melatonin or amitryptiline * Use of alcohol and drugs. * Be receiving prophylactic medication in the last three months. * History of hemiplegic migraine, basilar, Ophthalmoplegic or stroke. * Headache secondary to head trauma or a whiplash neck injury (whiplash). * Pregnant or breastfeeding. Women planning to become pregnant or of childbearing age without acceptable method of contraception. * Women who began taking oral contraceptives or who switched their oral contraceptive regimen in the 6 months prior to the start of the study. * Allergy or known hypersensitivity to study medication or its components. * Participation in another clinical study one month before inclusion.