Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities

University of Oslo100 enrolled

Overview

The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Periodontitis Vascular Disease

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis, Exclusion Criteria: * patients whom undergone antibiotic treatment the past month. * patients whom undergone periodontal treatment the past 6 months. * patients with no teeth

Locations (1)

Dental and Medical Faculty, University of Oslo

Oslo, Oslo, Norway

RECRUITING

Central Contacts

Ingar Olsen, Prof.PhD.

CONTACT

+47-22840350 ingar.olsen@odont.uio.no

Jørgen J Jørgensen, Prof.PhD

CONTACT

+47-22894496 j.j.jorgensen@medisin.uio.no

Data from ClinicalTrials.gov

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