A Study of the Pharmacokinetics and Safety of Varespladib in Subjects With Normal or Impaired Renal Function

Inclusion Criteria: * Males and non-pregnant, non-lactating females 18 years or older with a BMI of 18-40 kg/m2 inclusive. * Regarding renal function, subjects will be classified as either normal or as suffering from mild,moderate or severe renal impairment. Classification of renal impairment will be estimated by the MDRD and Cockcroft-Gault formulae Exclusion Criteria: * Any disease, condition and/or chronic medications which might compromise the hematologic, cardiovascular, pulmonary renal, gastrointestinal, hepatic, or central nervous system; or other conditions that might interfere with the distribution, metabolism or excretion of study drug, or would place the subject at increased risk * Evidence of significant respiratory, gastrointestinal or hepatic disease at screening * Positive screen for hepatitis B surface antigen, or HIV * Positive test in drugs of abuse screens or alcohol on admission to the clinic