31P-MRS and Huntington Disease

Institut National de la Santé Et de la Recherche Médicale, France30 enrolled

Overview

The purpose of this study is to identify and quantify a brain energy deficit in Huntington patients, using 31P-RMN spectroscopy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Huntington Disease

Interventions

31P-MR spectroscopyOTHER

Brain energy deficit is quantified using 31P-MR spectroscopy

31P-RMN spectroscopyOTHER

Brain energy deficit is quantified using 31P-RMN spectroscopy

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 5\<UHDRS\<50 * Age\>18 years * Ability to undergo MR scanning * Covered by french social security Exclusion Criteria: * Evidence of psychiatric disorder * Attendant neurological disorder * Contraindications to MRI (claustrophobia, metallic or material implants) * Severe head injury * Unable to understand the protocol * Pregnancy * Failure to give informed consent * Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent) * Unwillingness to be informed in case of abnormal MRI

Locations (1)

Hopital de la Pitié-Salpetrière

Paris, France

Outcomes

Primary Outcomes

Brain energy deficit in Huntington patients

31P-MRS allows quantification of high-energy phosphate metabolites such as ATP and phosphocreatine. Objective: to look at brain energy metabolism during rest and activation.

Time frame: one year

Secondary Outcomes

Correlating a brain energy deficit with (i) biochemical parameters and (ii) clinical parameters in Huntington patients

Biochemical parameters include metabolites that we previously showed to be biomarkers in HD: branched chain amino acids and IGF1. Clinical parameters include UHDRS and TFC.

Time frame: one year

Data from ClinicalTrials.gov

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