Hepatitis A Vaccine in Patients With Immunomodulating Drugs

Inclusion Criteria: * Diagnosis of rheumatoid arthritis * TNF-alfa blocker and / or methotraxate in use as a medication against RA * A desire to get protected against hepatitis A * Men and women age 18-65 years * Written informed consent * Women of childbearing potential must use effective contraception - Exclusion Criteria: * Treatment with rituximab within 9 months before study start * Known previous hepatitis A infection * Previous vaccination against hepatitis A * Allergy to eggs or formaldehyde * Pregnancy or lactation * Excessive use of alcohol * Mental retardation * Acute disease at the time of examination (fever \> 38 degrees) * Volunteer works as an employee of the researchers * Previous vaccination against hepatitis A * Egg-, henprotein- or formaldehyde allergy * Pregnancy or lactation * Excessive use of alcohol * Another vaccine given within a month * Acute disease at the time of examination (fever \> 38 degrees) * Not suitable for other reason in the investigator's opinion (other serious disease, i.e. AIDS/HIV-positive, cancer with ongoing cytostatic treatment)