Prospective Multicenter Trial to Explore the Tolerability and Safety of the H-Coil Deep TMS in Combination With Serotonin Selective Reuptake Inhibitor(SSRI)

Inclusion Criteria: * Outpatients * Men and women 22-68 years of age * Primary DSM-IV diagnosis of Major Depression, single or recurrent episode confirmed by the Structured Clinical Interview for the DSM-IV (SCID-IV). * Completed the CTP-0001-00 study according to the protocol, i.e., either completed 16 weeks of treatment, or were discontinued from the CTP-0001-00 study protocol after 6 weeks or more from randomization. * Capable and willing to provide informed consent. * Able to adhere to the treatment schedule. Exclusion Criteria: * Discontinued from CTP-0001-00 study protocol due to the following reasons: Tolerability and safety reason, Non-compliant with the study protocol, Developed documented suicidal ideation as assessed by the investigator or significant suicide risk based on HDRS-21 item 3 score of 3 or 4 or suicidal attempt * Current psychotic disorder * Sensitivity or allergic or other severe adverse event previously reported for Citalopram, Escitalopram, Fluoxetine, Paroxetine, or Sertraline. * Known or suspected pregnancy * Women of childbearing potential and not using a medically accepted form of contraception when engaging in sexual intercourse. * Minimal MT found for both hands is higher than 75% of stimulator power output.