Identifying Vitamin D Deficiency in Very Low Birth Weight Infant (VLBW) Infants Part 2

Medical University of South Carolina68 enrolled

Overview

This study is to determine the amount of vitamin D required for a very low birth weight infant to reach vitamin D sufficiency and achieve optimal calcium health and bone growth.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Infant, Very Low Birth Weight Calcium Deficiency Vitamin D Deficiency

Interventions

400 IU Cholecalciferol- Vitamin D DailyDIETARY_SUPPLEMENT

Infants who are defined as vitamin D deficient at birth will be randomized to receive either 400 IU vitamin D/day or placebo daily until term age is reached.

Eligibility

Sex: ALLMin age: 1 DayMax age: 3 Days

Medical Language ↔ Plain English

Inclusion Criteria: * Any infant born at the Medical University of South Carolina \<34 weeks gestation * Less that 1500g at birth * AGA * Must be African American or Caucasian * Each infant born of twin and triplet pregnancies will be eligible Exclusion Criteria: * Infants with major congenital anomalies or with hemolytic disease requiring exchange transfusion * Infants born small for-gestational-age (SGA) or large for-gestational-age (LGA) * Maternal uncontrolled thyroid disease * Maternal Parathyroid disease * Infants of races other than African American or Caucasian

Locations (2)

Medical University of South Carolina

Charleston, South Carolina, United States

Medical University of South Carolina

Charleston, South Carolina, United States

Outcomes

Primary Outcomes

Intestinal Calcium Absorption

Time frame: When receiving at least 50% of nutrition enterally expected to occur at 2-6 weeks post-birth

Parathyroid hormone concentration