Effect of HCO1100 on Cardiovascular Function

Inclusion Criteria: * Age ≥ 18 years * Dialysis dependent chronic renal failure (CKD 5) in a stable condition * Serum albumin at randomisation equal to or above the median of the normal range (pre- dialysis value) Exclusion Criteria: * Diabetes mellitus as the disease underlined end stage renal failure * Haemodynamic instability that precludes unsupported dialysis * planned surgical interventions \<= 4 months at time of inclusion * known allergy against dialysis membranes * Significant cardiac disease (atrial fibrillation, myocardial infarction within 6 months; unstable angina pectoris; LV-EF \< 30%, clinically significant pericardial disease; cardiac amyloidosis) * pulmonary disease with chronic hypoxia * Advanced disease or significant co-morbidity with poor short term prognosis, necessitating palliation and not subject to active or disease specific treatment * Clinically significant liver dysfunction (bilirubin \> 1.8mg/dl (30µmol/L)) * Prior fistula surgery on both arms or other operations or paralysis on both arms * Known HIV, HCV infection * Alcoholism * Active uncontrolled infection * Pregnancy or lactation * Inability to give informed consent to participate in the study