Local Infiltration With Bupivacaine to Increase Quality of Post-operative Pain Control in Total Knee Replacement

Mahidol University60 enrolled

Overview

The purpose of this study is to evaluate the efficacy of periarticular injection with 0.25% bupivacaine for controlling pain after total knee replacement to improve the quality of post-operative care.

Compare post operative pain control after total knee replacement by periarticular injection with 0.25% bupivacaine compare with 0.9% normal saline.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Pain, Postoperative Arthropathy of Knee Joint

Interventions

0.25% BupivacaineDRUG

Periarticular injection with 20 ml of 0.25% bupivacaine before wound closure.

0.9% normal salineDRUG

Periarticular injection with 20 ml of 0.9% normal saline before wound closure.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * primary osteoarthritis patients undergoing total knee replacement at Siriraj Hospital * BMI between 20-35 * having a full understanding of the question in this trial Exclusion Criteria: * allergy to NSAIDs, Acetaminophen, Bupivacaine * blood creatinine more than 1.5 mg/dl or creatinine clearance less than 60 mL/min * abnormal liver function * previous surgery on the knee undergoing total knee replacement * patient could not receive spinal anesthesia

Locations (1)

Siriraj Hospital

Bangkoknoi, Bangkok, Thailand

Outcomes

Primary Outcomes

Post operative pain

Measure by Visual analog scale scores and morphine consumption

Time frame: 96 hour post operation

Secondary Outcomes

Complication of Morphine consumption

nausea, pruritis, urinary retention and constipation

Time frame: 96 hour post operation

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.