Unrelated Donor Stem Cell Transplantation

Scripps Health64 enrolled

Overview

The purpose of this study is to provide an opportunity for patients with malignancies or bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries.

same

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Severe Aplastic Anemia Paroxysmal Nocturnal Hemoglobinuria Acute Myelogenous Leukemia Acute Lymphoblastic Leukemia Myelodysplastic Syndromes

Eligibility

Sex: ALLMin age: 18 YearsMax age: 69 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \> 18 years of Age * \< 70 years * ECOG performance status 0, 1 or 2 * Left Ventricular Ejection Fraction \> 30% * Creatinine clearance \> 40ml/min * Transaminases \< 2X normal * Total bilirubin \< 2X normal * HIV seronegativity * Weight \< 70kg for cord blood transplantation * Ability to cover the cost of the transplant, necessary medications, and transportation/housing. * Caregiver must be available while outpatient Exclusion Criteria: * Greater than one antigen mismatch at HLA-A, B, C or DR plus one allele mismatch at HLA-A, B, C or DR

Outcomes

Primary Outcomes

Bone Marrow and Peripheral Blood Chimerism

Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing.

Time frame: 30 days post-transplant

Bone Marrow and Peripheral Blood Chimerism

Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing.

Time frame: 100 days post-transplant

Bone Marrow and Peripheral Blood Chimerism

Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing.

Time frame: 365 days post-transplant

Unrelated Donor Stem Cell Transplantation

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes