The combination of pEBV DNA (half-life) and PET-CT following 1 course of chemotherapy allow earlier and more detection of drug response in advanced NPC than RECIST method, in patients with previously untreated advanced NPC who will receive platinum-based chemotherapy. This study will also determine if this new method can predict survival in these patients. This study may have far-reaching impact on drug development in NPC as it may offer a more optimal way of evaluating drug efficacy in clinical trials and also in clinical management.
Study Type
OBSERVATIONAL
Enrollment
70
platinum-based chemotherapy
Department of Clinical Oncology, Prince of Wales Hospital
Hong Kong, Hong Kong
To determine if measuring tumor metabolic response during chemotherapy can predict survival
Time frame: 3 years
To determine if measuring plasma EBV DNA (half-life) early during chemotherapy can predict survival
Time frame: 3 years
New method of assessing drug response (measuring tumor metabolic response via FDG-PET & plasma EBV DNA (half-life) after 1 course of chemotherapy) can better predict survival, than the conventional method
Time frame: 3 years
To determine if plasma EBV DNA (half-life) correspond with best response rate based on the conventional 'Response Evaluation Criteria in Solid Tumors' - RECIST criteria.
Time frame: 3 years
overall survival
Time frame: 3 Years
progression free survival
Time frame: 3 Years
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