Biomarker in Tumor Tissue Samples From Patients With Rhabdomyosarcoma

Children's Oncology Group60 enrolled

Overview

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in tumor tissue samples from patients with rhabdomyosarcoma.

OBJECTIVES: * To determine and quantify the degree of surface insulin-like growth factor I receptor (IGF-IR) expression in rhabdomyosarcoma (RMS) tumor tissue. * To assess the feasibility and validity of a mass spectrometry assay for IGF-IR expression on paraffin-embedded tumor tissue. OUTLINE: Paraffin-embedded tumor tissue slides are analyzed for insulin-like growth factor I receptor (IGF-1R) expression by mass spectrometry and correlated with the results obtained by IHC assay.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sarcoma

Interventions

gene expression analysisGENETIC

immunohistochemistry staining methodOTHER

laboratory biomarker analysisOTHER

mass spectrometryOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosis of rhabdomyosarcoma * Alveolar or embryonal rhabdomyosarcoma * Available samples from the Cooperative Human Tissue Network (CHTN) bank PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Degree of surface IGF-IR expression in RMS tumor tissue

Feasibility and validity of a mass spectrometry assay for IGF-IR expression on paraffin-embedded tumor tissue

Data from ClinicalTrials.gov

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