Renal Denervation in Patients With Resistant Hypertension and Obstructive Sleep Apnea

National Institute of Cardiology, Warsaw, Poland60 enrolled

Overview

The purpose of this study is to investigate the clinical utility of renal denervation for the treatment of resistant hypertension coexisting with obstructive sleep apnea.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hypertension Obstructive Sleep Apnea

Interventions

Renal denervation with a catheter-based procedure (Symplicity® Catheter System)DEVICE

Disruption of the renal nerves with a catheter-based procedure.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \>= 18 and =\< 70 years of age. * systolic blood pressure \>=140mmHg (office); * on 3 or more antihypertensive medications (including diuretic) * mean daytime systolic ABPM \>= 135 mmHg * obstructive sleep apnea (AHI \>=15 event/hour, indications for CPAP treatment) Exclusion Criteria: * renal artery abnormalities * eGFR \< 60mL/min * previous TIA, stroke, heart failure * Type 1 diabetes * ICD or pacemaker * others

Locations (1)

Institute of Cardiology

Warsaw, Poland

Outcomes

Primary Outcomes

Blood Pressure Reduction

Time frame: 3 months

Secondary Outcomes

Responses to renal denervation (e.g., blood pressure reduction, sleep apnea course, metabolic assessment, cardiac changes)

Time frame: Through 1 year

Data from ClinicalTrials.gov

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