Gut Hormones After Oral Versus Intravenous Amino Acids

Lund University12 enrolled

Overview

The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.

Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects. Samples are taken regularly for 300 min after administrations. Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Normal Non-fluency

Interventions

Oral amino acid mixtureOTHER

Amino acid mixture 2,93 ml/kg

Intravenous amino acid administrationOTHER

Amino acid mixture 2,93 ml/kg

Eligibility

Sex: MALEMin age: 20 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy subjects Exclusion Criteria: * Diabetes * Liver disease * Kidney disease * Thyroid disease

Locations (1)

Department of Clinical Sciences Lund, Lund University

Lund, Sweden

Outcomes

Primary Outcomes

Gut hormone secretion

Time frame: 300 min

Secondary Outcomes

Insulin secretion

Time frame: 300 min

Data from ClinicalTrials.gov

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