To evaluate the pharmacokinetics of single oral dose of Amitriptyline hydrochloride film-coated tablet 10mg \& 25mg
Randomized, Single dose, 2-way crossover, Open Study to compare the pharmacokinetics profile of Etravil®(Amitriptyline Hydrochloride) Tablet 10mg and Etravil®(Amitriptyline Hydrochloride) Tablet 25mg after a single oral administration in healthy male volunteers
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
12
Chonbuk National University Hospital.
Jeonju, Jeollabuk-do, South Korea
AUClast and AUCinf
Area Under the Plasma concentration-time curve from time Zero to Infinity(AUCinf) and Area Under the Plasma concentration-time curve from time Zero to last time(AUClast) of Amitryptiline in plasma
Time frame: Up to 72 hours
Cmax
Maximum Concentration(Cmax) of amitryptyline in plasma
Time frame: Up to 72 hours
Tmax
Time for Maximum Concentration(Tmax) of Amitryptyline in Plasma
Time frame: Up to 72 hours
t1/2
Terminal half-time(t1/2) of Amitryptyline in Plasma
Time frame: Up to 72 hours
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