Effects of "in UTERO" Exposure to Glucocorticoids

Inclusion Criteria: * Over 18 years Aged * Males * Women of childbearing age with a reliable and effective contraception for over 2 months * Taking dexamethasone between the 6th and the 24th week of gestation by the mother with bloc 21-hydroxylase or normal pregnancy for control subjects * Normal blood pressure and heart rate measured at rest: systolic blood pressure \<= 150 mmHg, diastolic blood pressure \<= 90 mmHg, heart rate between 55 and 90 beats/mn. * Normal laboratory tests or not clinically significant abnormality NFS, platelets PT, aPTT, fibrin TP, TCA, Serum electrolytes, urea, creatinine Uric acid Triglycerides, total cholesterol, HDL cholesterol * Fating bood glucose \<= 6.9 mmol/l (exclusion criteria for diabetes from the American Diabetes Association) during the OGTT. * Negative blood HCG * Accepting the constraints of the protocol and had signed informed and free consent. * Affiliated to the Social Security. Exclusion Criteria: * Affected offspring of 21-hydroxylase enzyme block * Taking dexamethasone until pregnancy term by the mother of the subject * Type 2 diabetes in one of the two parents and/or 1 of the 4 grandparents * Pregnancy, Breastfeeding * Body Mass Index (weight/height2)\> 50 kg/m2 * Poisoning smoking (\>10 cigarettes per day, whatever the duration of intoxication) * Any drug taken apart from minor analgesics (aspirin, paracetamol) for less than 8 days at the inclusion and oral contraception * Taking recent (less than 3 months) glucocorticoids either taken orally, by inhalation or percutaneously * Current infections or recent infections (\<10 days) * Neoplastic disorders (with the exception of carcinoma in situ of the cervix or cutaneous epithelioma), haematological, cardiovascular, psychiatric, neurological * Having donated blood or participated in a trial within 2 months preceding their inclusion