Cardiac MR (CMR) will be used to assess myocardial activation and hemodynamics in patients with CRT. Goals are to demonstrate that * differences in Left ventricle (LV)- right ventricle (RV) pacing delays cause differences in myocardial activation * differences in LV-RV pacing delays cause differences in LV/RV hemodynamics and to use these data to optimize CRT.
CMR will be performed in patients under CRT who are currently not responding to CRT. Different LV-RV delays will be programmed during CMR and LV function and different dyssynchrony parameters will be assessed. Results will be used to determine the optimal LV-RV delay, and CRT-devices will be reprogrammed accordingly. Improvement in NYHA-class/conversion to therapy responder will be determined clinically after 3 months.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
1
CRT devices will be reprogrammed according to CMR analysis
University Hospital, University of Bonn
Bonn, North Rhine-Westphalia, Germany
improvement in NYHA-class
Time frame: 6 months
safety of CMR in CRT-patients
pacing capture threshold, sensing and lead impedances will be monitored for significant and/or clinically relevant changes.
Time frame: 6 months
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