This is a randomized placebo-controlled trial studying the effects of intraoperative continuous airway pressure (CPAP) on the inflammatory response of the lung with cancer undergoing lobectomy.
Pulmonary lobectomy induces an inflammatory response of this lung caused by intraoperative atelectasis and re-expansion. This inflammatory response can be attenuated with treatment, also decreasing postoperative pulmonary complications (PPC). Thus, avoiding complete atelectasis with partial insufflation of the lung during surgery could be useful to decrease inflammatory response and PPC.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
To evaluate if continuous positive airway pressure (CPAP) on the lung undergoing lobectomy can decrease the inflammatory response and PPC.
Hospital del Mar
Barcelona, Spain
RECRUITINGAlveolar and plasmatic cytokines measured before and after atelectasis and re-expansion.
Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion.
Time frame: From preoperative to postoperative (24h) period.
Alveolar MICA
Alveolar MICA I (major histocompatibility complex (MHC) class I chain related genes) expression measured at the same control times.
Time frame: From preoperative to postoperative period (24h)
CT-Scan
Postoperative distribution of well-aerated, non aerated or poorly aerated lung volumes.
Time frame: 22-24h after surgery
Postoperative pulmonary complications (PPC).
PPC.
Time frame: Participants will be followed for the duration of hospital stay, an expected average of 10 days.
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