Long-Term Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children Who Completed OTR3001

Inclusion Criteria include: 1. Male and female patients aged 6 to 17 years, inclusive, who completed the 4-week study drug treatment in study OTR3001 and who, based on the investigator's judgment, will benefit from continuing treatment with oxycodone HCl CR 20 to 240 mg/day for the management of moderate to severe malignant or nonmalignant pain; 2. Patients must have tolerated the oxycodone HCl CR therapy in OTR3001 as demonstrated at the start of the study; 3. Patients must be willing and able to swallow the oxycodone HCl CR tablets whole. Exclusion Criteria include: 1. Patients with ongoing adverse events in OTR3001 that, in the investigator's opinion, disqualify them from participation in the study; 2. Female patients who are pregnant or lactating; 3. Patients requiring opioid at doses equivalent to \< 20 mg/day or \> 240 mg/day oxycodone for treatment of their malignant or nonmalignant pain; 4. Patients who are allergic to oxycodone or have a history of allergies to other opioids (this criterion does not include patients who have experienced common opioid side effects \[eg, nausea, constipation\]); 5. Patients who are contraindicated for the use of opioids; 6. Patients who are currently being maintained on methadone for pain; 7. Patients who have an abnormality on vital signs, physical examination, or laboratory testing significant enough that the investigator deems the patient is not appropriate for the study; 8. Patients who have any planned surgery during the course of the study, with the exception of the placement of central or peripheral venous access devices; 9. Patients currently taking an investigational medication/therapy other than the study drug (oxycodone HCl CR) at the start of screening or during the study. Other protocol specific inclusion/exclusion criteria may apply.