The Effects of Preservative-free Prostaglandin Eye Drops in Sign and Symptoms on the Eyes of Patients With Glaucoma

Inclusion Criteria: * Have provided a written informed consent * Aged 18 years or more * A diagnosis of ocular hypertension or open-angle glaucoma (either POAG or capsular glaucoma) in one or both eyes, for which the patient has been regularly using latanoprost 0.005% (Xalatan®) for at least six months before Screening (confirmed in anamnesis) * In the Screening visit evaluation, the presence of: At least two ocular symptoms considered for the two eyes together (irritation/burning/stinging, foreign body sensation, tearing, itching or dry eye sensation) of at least mild severity (grade ≥ 2) upon non-instillation OR One ocular symptom of at least mild severity (grade ≥ 2) upon non-instillation AND At least one of the following ocular signs in either eye with prior treatment: Fluorescein tear break-up time (fBUT): less than 10 seconds Corneal and conjunctival fluorescein staining: Corneal fluorescein staining score of at least grade I OR Combined nasal and temporal staining scores of at least grade II Blepharitis: of at least mild severity (grade ≥ 1) Conjunctival redness/hyperemia: of at least mild severity (grade 1) Tear production: 10 mm or less on Schirmer test * A best corrected ETDRS visual acuity score of +0.6 logMAR or better in both eyes * Negative pregnancy test result at the screening visit, or, consistently and correctly used reliable method of contraception during the study * Are willing to follow instructions Exclusion Criteria: * Females who are pregnant, nursing or planning a pregnancy, or females of childbearing potential who are not using a reliable method of contraception * Anterior chamber angle in either eye to be treated less than grade 2 according to Schaffer classification as measured by gonioscopy * Any corneal abnormality or other condition preventing reliable applanation tonometry, including prior refractive eye surgery * IOP greater than 22 mmHg at 15:00 IOP measurement in either eye at Screening/Baseline visit * Use of preserved eye drops (other than latanoprost) including artificial tears at screening or within two weeks prior to screening visit * Diagnosis of angle-closure glaucoma or secondary glaucoma other than capsular glaucoma in either eye * Suspected contraindication to tafluprost therapy (hypersensitivity to tafluprost or any of the excipients) * Glaucoma filtration surgery or any other ocular surgery (including ocular laser procedures) within 6 months prior to Screening in eye(s) to be treated with study medication * Use of contact lenses at Screening or during the study * Any ocular (e.g. aphakia, pseudophakia with torn posterior lens capsule2 or anterior chamber lenses,known risk factors for cystoid macular oedema or iritis/uveitis), systemic or psychiatric disease/condition (e.g.uncontrolled arterial hypertension, diabetes) that may put the patient at a significant risk or may confound the study results or may interfere significantly with the patient's participation in the study as judged by the investigator * Current alcohol or drug abuse * Current participation in another clinical trial involving an investigational drug/device, or participation in such a trial within the last 30 days