Therapy to Elevate CD4 Counts in HIV-1 Disease

Inclusion Criteria: 1. HIV-1 patients must have confirmed HIV-1 disease, diagnosed using the standard criteria and be on antiretroviral therapy. Patients with inherited alpha-1 proteinase inhibitor deficiency (PIzz) must not have previously received alpha-1 proteinase inhibitor therapy. Uninfected volunteers will be age and gender matched. 2. HIV-1 patients must have measurable disease, defined as HIV-1 infected patients on antiretroviral therapy with undetectable HIV RNA (\<500 HIV-1 RNA copies/ml) and CD4 counts more than 200 and less than 400 cells/uL. 3. Age at least 18 years and under 65 years. 4. HIV-1 patients must have active alpha-1 proteinase inhibitor below 11uM (normal is 18-53 uM). 5. HIV-1 patients must have one year history (prior to the study) with CD4 counts greater than 200 and less than 400 cells/uL. 6. Volunteers must have no evidence of malignancy. Exclusion Criteria: 1. Recent illness that will prevent the patient from participating in required study activities. 2. Patients receiving other investigational agents. 3. Patients with known malignancies. 4. Patients with more than 500 HIV RNA copies/mL. 5. Patients with more than 400 CD4 cells/uL. 6. Uncontrolled illness including, but not limited to, ongoing or active infection, myeloid dysplastic syndrome, anemia, bone marrow failure, DiGeorge Syndrome, thymic disorders, or psychiatric illness/social situations that would limit compliance with study requirements.