This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of multiple dose treatment with MK-1029 in adults with mild to moderate persistent asthma.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
27
Five (5) X 100 mg capsules, orally, once daily for 28 days
Five (5) X 100 mg capsules, orally, once daily for 28 days
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Costa Mesa, California, United States
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Rolling Hills Estates, California, United States
Merck Sharp & Dohme
North Ryde, Australia
Merck Sharp & Dohme (New Zealand) Ltd.,
Wellington, New Zealand
Number of Participants Who Experienced One or More Adverse Events
An adverse event (AE) is any untoward medical occurrence in a study participant administered a pharmaceutical product that does not necessarily have to have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign, symptom, or disease temporally associated with the use of a medicinal product, whether or not related to the medicinal product.
Time frame: Up to 42 days after initial dose of study treatment
Number of Participants Who Discontinued Study Treatment Due to An Adverse Event
An AE is any untoward medical occurrence in a study participant administered a pharmaceutical product that does not necessarily have to have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign, symptom, or disease temporally associated with the use of a medicinal product, whether or not related to the medicinal product.
Time frame: Up to 28 days after initial dose of study treatment
Area Under the Concentration-Time Curve From Time 0 to 6 Hours (AUC0-6hr) of MK-1029
Blood was collected on Day 1 and Day 28 at predose and 1, 2, 3, 4 and 6 hours postdose for determining the Cmax of MK-1026.
Time frame: Day 1 and Day 28: Predose, 1, 2, 3, 4, and 6 hours postdose
Maximum Plasma Concentration (Cmax) of MK-1029
Blood was collected on Day 1 and Day 28 at predose and 1, 2, 3, 4 and 6 hours postdose for determining the Cmax of MK-1026.
Time frame: Day 1 and Day 28: Predose, 1, 2, 3, 4, and 6 hours postdose
Time to Maximum Plasma Concentration (Tmax) of MK-1029
Blood was collected on Day 1 and Day 28 at predose and 1, 2, 3, 4 and 6 hours postdose for determining the Tmax of MK-1026.
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MSD (Pty) LTD South Africa
Midrand, South Africa
Time frame: Day 1 and Day 28: Predose, 1, 2, 3, 4, and 6 hours postdose