Efficacy of Esomeprazole in Patients With Frequent Heartburn

Number of Subjects Reporting Heartburn 2 Days or Less During the 14 Days Randomized Treatment Period

Treatment period is considered to be both weeks 1 and 2 between V3 and V4.

Time frame: From randomisation to the day 14

Comparison of Number of Subjects With 0, 1, 2, 3 or 4 Days With no Heartburn Over Days 1 to 4 Between Esomeprazole 20 mg and Placebo

The first 4 consecutive days subjects were on randomized treatment, between V3 and V4.

Time frame: From randomisation to day 14

Number of Subjects With Heartburn 1 Day or Less During the Final Week, Second Week, First Week of Treatment

There were three separate 7 day time periods during the treatment period; The first week (days 1-7), the second week (days 8-14), and the last 7 consecutive days (last day subject reported and the prior 6). For a given subject, the second week and last 7 consecutive days are the same if the subject has recorded measurements for the entire 14 day treatment period. However, for subjects reporting anything less than 14 days the two will not be identical. For all three 7 day time periods, days when a subject did not call in (i.e., missing values) were imputed as a day with heartburn.

Time frame: From randomisation to day 14