Thrombotic event is one of the most serious complications of coronary artery disease, which often result in myocardial infarction and even death. Even according to the standard guidelines for antiplatelet therapy, there are still 6% to 15% of patients occur thrombotic events, in high-risk patients, the proportion is higher, this phenomenon is called anti-platelet drug resistance in clinical practice The aim of this multicenter prospective, randomized, controlled study is to observed policosanol on aspirin or clopidogrel resistance in patients with platelet aggregation after Percutaneous Coronary Stent Implantation (PCI) and occurrence of platelet aggregation and short-term prognosis to find new ways to the prevention of platelet aggregation .
Thrombotic event is one of the most serious complications in coronary artery disease, which often result in myocardial infarction and even death. Even according to the standard guidelines for antiplatelet therapy, there are still 6% to 15% of patients occur thrombotic events, in high-risk patients, the proportion is higher, this phenomenon is called anti-platelet drug resistance in clinical practice
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
350
clopidogrel 150 mg/d for 30 days followed by 75 mg/d for at least 1 year; aspirin 300mg/d for 1 month followed by 100mg/d chronically;
clopidogel 75mg/d for at least 1 year; aspirin 300mg/d for 1 month followed by 100mg/d chronically;
aspirin 300 mg/d for 1 month followed by 100 mg/d chronically; clopidogrel 75 mg/d for at least 1 year policosanol 40mg/d for 6 months
The First Hospital of China Medical University
Shenyang, Liaoning, China
reversion rate of HPR
reversion was defined as platelet aggregation \<65%
Time frame: 30 days
major adverse cardiovascular events
including cardiac death, non-fatal myocardial infarction and target vessel revascularization
Time frame: 1 year
Stent thrombosis and TIMI bleeding events
Time frame: 1 year
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