A Study of RO5428029 in Healthy Volunteers and Patients With Chronic Hepatitis C

Inclusion Criteria: * Healthy subjects (Part A) or patients with chronic hepatitis C infection (Part B), 18 to 60 years of age, inclusive * Body mass index (BMI) between 18 and 32 kg/m2, inclusive, and a minimum weight of 45 kg * Female subjects/patients must be surgically sterile or post-menopausal * Male subjects/patients and their partners of childbearing potential must use 2 methods of contraception * For HCV patients: * Hepatitis C genotype 1 of \> 6 months duration at screening * HCV RNA quantifiable (Roche COBAS TaqMan HCV Test) at screening * HCV treatment-naïve (no prior antiviral therapy for chronic hepatitis C with interferon-based therapy) * Liver biopsy or non-invasive procedure within the past 2 years showing absence of cirrhosis Exclusion Criteria: * Pregnant or lactating women, and male partners of women who are pregnant or lactating * Positive test for drugs of abuse * History (within 3 months of screening) of alcohol consumption exceeding 2 standard drinks per day on average (1 standard drink = 10 grams or 1 unit of alcohol * History or symptoms of any significant disease or disorder * History of active malignancy within the last 5 years, except for localized or in situ carcinoma (e.g. basal or squamous cell carcinoma of the skin) * Positive for hepatitis B or HIV infection, and/ or for HCV for healthy volunteers (Part A) * For HCV patients: * Decompensated liver disease or impaired liver function as defined by any history of ascites, hepatic encephalopathy, hepatocellular carcinoma or bleeding esophageal varices, or prothrombin international normalized ratio (PTINR) \>/= 2.0 at screening * Evidence of cirrhosis and/or incomplete transition to cirrhosis * Presence or history of non-hepatitis C liver disease