Adiponectin (Ad) is an abundant protein in human body, and reports have shown that it act as a novel risk factor for brain and heart ischemia injury. This 5 years follow-up study will focus on serum adiponectin concentration, activity and isoforms in Chinese population and its correlation to these diseases.
Adiponectin (Ad) is an abundant protein hormone regulatory of numerous metabolic processes, anti-inflammatory, vascular protective, and anti-ischemic properties. Since its 1995 discovery, Ad has garnered considerable attention for its role in diabetic and cardiovascular pathology. Clinical observations have demonstrated the association of hypoadiponectinemia in patients with obesity, cardiovascular disease, and insulin resistance. There is growing evidence supporting Ad can act as a novel risk factor for cardiovascular and cerebrovascular injury. This 5 years follow-up study will focus on serum adiponectin concentration, activity and isoforms in Chinese population and its correlation to cardiovascular and cerebrovascular diseases.
Study Type
OBSERVATIONAL
Enrollment
30,000
Xijing Hospital
Xi'an, Shaanxi, China
RECRUITINGNumber of Participants with major adverse events
Major adverse events included but were not limited to death during the study caused by cardiovascular events or cerebrovascular events.
Time frame: 5 years
blood routine, glucose and lipid profile; ECG;
the tests mentioned above will be taken once per year
Time frame: 5 years
serum adiponectin concentration, activity and isoforms
serum adiponectin concentration, activity and isoforms will be monitored once per year.
Time frame: 5 years
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