Compare with regular regimen, the aim of this study is to testify whether having more statin during PCI will benefit in Chinese population, and to find out optimal dose of the drug for patient after PCI.
This study is designed to find out whether patients undergoing PCI can benefit from intensive atorvastatin treatment compared with routine treatment on chinese population.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
300
Atorvastatin 80mg/d ×2d before PCI. After PCI, atorvastatin 40mg/d until 30 days later, and then followed by usual care
Usual care, but statin dose should not be higher than that described in exclusion criteria
Xijing Hospital
Xi'an, Shaanxi, China
RECRUITING30-day major adverse cardiovascular events (combined endpoints of cardiac death, myocardial infarction, and target vessel revascularization ) after PCI
Time frame: 30-day
Post-procedural change of inflammatory biomarkers (hs-CRP)
Time frame: 24h
Morbidity of CIN
Time frame: 48h
Elevation of ALT, AST and CK
Proportion of patients who experience at least once AST\>3UNL,ALT\>3UNL or CK\>5UNL after initiation of study treatment. Proportion of patients who experience at least once AST, ALT, or CK\>UNL after initiation of study treatment.
Time frame: 6 months
Number of Participants with Adverse Events
Proportion of patients who take reduced dose of atorvastatin, withdraw study treatment, or withdraw study due to adverse events
Time frame: 6 months
Combined endpoint of MACEs, cardiac hospitalization and cerebrovascular events
Combined endpoint of death, cardiac death, myocardial infarction, heart failure, cardiac hospitalization, revascularization, and cerebrovascular events within 6 months after PCI.
Time frame: 6 months
serum adiponectin concentration
Time frame: 6 months
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