The Effects of Soy Dietary Fiber in Adults With Diarrhea Predominant Irritable Bowel Syndrome

Seoul National University Hospital36 enrolled

Overview

The investigators will evaluate the efficacy of soy dietary fiber in adults with diarrhea predominant irritable bowel syndrome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Diarrhea Predominant Irritable Bowel Syndrome

Interventions

Soy Dietary FiberDIETARY_SUPPLEMENT

Soy Dietary Fiber, Once a day, before meal, 1 pack(20g), per oral with water 90mL

Rice powderDIETARY_SUPPLEMENT

Rice powder, Once a day, before meal, 1 pack(20g), per oral with water 90mL

Eligibility

Sex: ALLMin age: 19 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * willing to consent/undergo necessary procedures * between the age of 19 and 75 years * diarrhea predominant irritable bowel syndrome (satisfied with Rome II criteria) Exclusion Criteria: * uncontrolled hypertension (Blood pressure \> 170/100 mmHg) * uncontrolled diabetes mellitus (FBS \> 180 mg/dL) * malignancy, cerebrovascular disease, cardiovascular disease * history of abdominal surgery except appendectomy and hernia repair * inflammatory bowel disease * clinically or laboratory-confirmed gastroenteritis * the use of motility drug or dietary fiber supplement in 2 weeks * allergy to soy fiber * serum Cr \> 2 x Upper normal limit * AST or ALT \> 2 x Upper normal limit * Pregnancy, Lactating woman

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

sum of irritable bowel syndrome symptom score

abdominal pain / abdominal discomfort urgency tenesmus abdominal distension

Time frame: after 4 weeks