This study assesses the safety, tolerability, pharmacokinetics and pharmacodynamics of ASP1941 orally administered as single doses to healthy adult male Taiwanese subjects.
The subjects will be administered a single dose of ASP1941 or placebo under fasting condition. Plasma and urine levels of ASP1941 and glucose will be measured to investigate pharmacokinetic and pharmacodynamic properties of ASP1941.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
56
Unnamed facility
Taipei, Taiwan
Safety assessed by the incidence of adverse events, vital signs, safety lab tests and 12-lead ECG
Time frame: up to 72 hours
Cmax of ASP1941 plasma concentration
Time frame: up to 72 hours
AUC (Area under the curve) of ASP1941 plasma concentration
Time frame: up to 72 hours
Changes in plasma glucose
Time frame: baseline and up to 72 hours
Changes in urine glucose
Time frame: baseline and up to 72 hours
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