Efficacy and Safety of Oltipraz in the Patients With Non-alcoholic Fatty Liver Disease

Inclusion Criteria: * Patients over 18, under 75 years of age * Patients with non-alcoholic fatty liver disease Exclusion Criteria: * Over 2 ratio of AST to ALT * Type 1 diabetes mellitus (insulin-dependent diabetes mellitus) * Disorder in liver function with an exception of non-alcoholic fatty liver (e.g. Virus infection, biliary atresia, autoimmune hepatitis and etc.) * Patients who have been taken drugs induced fatty liver for over 3 month within 1 year of participation in this study; amiodarone, tamoxifen, methotrexate, tetracyclines, glucocorticoids, anabolic steroids, over usual dose of estrogen for hormone replacement therapy and valproate * Patients who has been taken any medications that could affect the treatment for non-alcoholic steatohepatitis: insulin, insulin sensitizer(metformin, thiazolidinedione), high dose of vitamin E, high dose of UDCA, pentoxifylline, SAM-e, Betaine, types of Statin, types of fibrate and orlistat * Patients who had a Bariatric surgery less than 6 month prior to the participation in the study * Patients who are judged by investigator that participation of the study is difficult due to disease as follow; hepatic cirrhosis, Wilson's disease, malignant tumor, serious metabolic disease, severe renal disease, severe pulmonary disease, severe cardiovascular disease, severe nervous disease/psychiatric disorder, muscle disease and etc * Any history of immune disorder which affect the changes in cytokine: inflammatory bowel disease, autoimmune thrombocytopenic purpura, system lupus erythematosus, autoimmune hemolytic anemia, severe psoriasis, rheumatic arthritis and etc * Patients who have received treatment that may affect liver function within 1 month prior to the participation in the study * Patient who has been administered other investigational product within 1 month prior to the participation in the study * Patient who is not allowed to get MRS test: pacemaker, shunt and etc * Pregnant or nursing women * Patient who considered ineligible for participation in the study as Investigator's judgment