A Study of Terlipressin in Patients With Hepatorenal Syndrome Type 1

Inclusion Criteria: \- Patients who were diagnosed with HRS type 1 according to the diagnostic criteria of HRS and whose serum creatinine value (SCr) doubled at 2.5 mg/dL or greater within 2 weeks or whose 24h creatinine clearance (Ccr) decreased by half at less than 20 mL/min. Patients should meet all the following 5 criteria: \[Modified International Ascites Club's Diagnostic criteria of HRS\] 1. Chronic or acute liver disease with advanced hepatic failure and portal hypertension. 2. Low glomerular filtration rate (SCr \>1.5 mg/dL or 24h Ccr \<40 mL/min) 3. Absence of shock, ongoing bacterial infection, current or recent (within 2 weeks) treatment with nephrotoxic drug 4. No sustained improvement in renal function (decrease in SCr to 1.5 mg/dL or less or increase in 24h Ccr to 40 mL/min or more) following diuretic withdrawal and expansion of plasma volume with 1,500 mL/24h of isotonic saline for 24 to 48h. 5. Protein urea \<500 mg/dL, and no ultrasonographic evidence of obstructive uropathy or parenchymal renal disease * Age; 20 to 79 years Exclusion Criteria: * Cr value ≥5 mg/dL * Child-Pugh Score ≥14 * Fulminant hepatitis * Septic shock * Hepatocellular carcinoma that does not meet the Milan Criteria * Acute renal failure caused by contrast medium * Chronic renal failure * Bradycardia (heart rate \<50/min) * Hyponatraemia (serum Na \<120 mEq/L) * Ischemic heart diseases (angina pectoris, myocardial infarction), heart failure or clinically relevant arrhythmia * Poor-controlled hypertension * Arteriosclerosis obliterans or peripheral vascular disorder * Cerebrovascular disorder * Respiratory diseases such as chronic obstructive pulmonary disease * Pregnant or possibly pregnant women and patients who or whose partner desire -pregnancy during the study period * Patients considered by the investigator or sub-investigator as unsuitable to participate in the study