Nitro Oxide (NO) inhalation was recognized as an effect treatment of Neonatal Persistent Pulmonary Hypertension (PPHN), while the safety of NO long term application was under investigation. Several research suggested too much NO2 was generated in the lung after long term (\> 72h) use of NO inhalation, which cause bad effects on PS production. Sildenafil was proved to be effective to PPHN as NO. This medication has a similar clinical effect but need monitoring of blood pressure. The possible hypotension effect restrict the dosage of sildenafil, which limit the usage of sildenafil in severe PPHN. But we recommend sildenafil to The purpose of the study was to establish if NO continued with sildenafil has the same effect as single NO inhalation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
40
NO inhalation was performed as the only treatment for PPHN during the whole course.
NO inhalation was performed as the primary treatment for PPHN in the first 48 hours, NO inhalation will be replaced by sildenafil after 48 hours of therapy.
Department of Pediatrics,Daping hospital
Chongqing, Chongqing Municipality, China
RECRUITINGpersistent normal pulmonary artery pressure
The pulmonary artery pressure returned back to a normal level(\<30mmHg) and last over 48 hours.
Time frame: 96 hours
Recover without complication
To ensure the safety of the therapies, brain and lung complications of the baby after PPHN is going to be observed 1 month after birth. 1. incidence of pulmonary disease;(chronic lung disease) 2. incidence of brain injury. (Hypoxic-ischemic encephalopathy) 3. Heart structure change(right ventricle enlarge)
Time frame: 1 month after therapy
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