Importance of Meal Fat Content and Gall Bladder Emptying for Postprandial GLP-1 Secretion in Type 2 Diabetes Patients

University Hospital, Gentofte, Copenhagen30 enrolled

Overview

PURPOSE The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology. In the present study the investigators examine the GLP-1 secretion in healthy subjects and in Type 2 Diabetes Mellitus (T2DM) patients. The investigators hypothesize that patients with T2DM of relatively long duration will be characterized by reduced gall bladder emptying, and, consequently, reduced intestinal TGR5 activation; resulting in attenuated postprandial GLP-1 responses (primary endpoint).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diabetes

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: (Healthy) * HbA1 \< 6 % * Normal haemoglobin levels * Informed content Inclusion Criteria: (T2DM) * T2DM \> 5 years * Normal haemoglobin levels * Informed content Exclusion Criteria: (T2DM) * Treatment with insulin, DPP-IV inhibitor or GLP-1 analogues * Obesity (BMI \> 30) * Age \> 70 years * Gastrointestinal disease * Nephropathy * Liver disease * Medication which cannot be on hold for 12h * Gastrointestinal surgery Exclusion Criteria: (Healthy) * 1st degree relatives with diabetes * Obesity (BMI \> 30) * Age \> 70 years * Gastrointestinal disease * Nephropathy * Liver disease * Medication which cannot be on hold for 12h * Gastrointestinal surgery

Importance of Meal Fat Content and Gall Bladder Emptying for Postprandial GLP-1 Secretion in Type 2 Diabetes Patients

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes