Assessing the Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers

Mashhad University of Medical Sciences20 enrolled

Overview

The purpose of this study is to determine whether propolis is effective in the treatment and prevention of radiotherapy induced oral mucositis.

Patients with head and neck malignancy with inclusion criteria randomly divide in 2 groups and take the intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Radiation-induced Mucositis of Oral Mucous Membranes

Interventions

propolisDRUG

15 ml mouth wash 3 times a day for the whole period of radiotherapy for 5 min swish and then swallow

Eligibility

Sex: ALLMin age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: - age \>15 * need of radiotherapy * at least half of the mouth in the field of radiation * dose 50 -70 Gy * head \& neck malignancy Exclusion Criteria: * systemic disease * FBS \> 150 WBC \> 3000 * history of radiotherapy * need of chemotherapy * systemic disease

Locations (1)

Mashhad University of Medical Science

Mashhad, Khorasan Razavi, Iran

Outcomes

Primary Outcomes

NCI.CTC Scale

we use NCI-CTC scale for patients in 2 groups to assess effect of propolis mouth wash on prevention and treatment of mucositis in patients under radiotherapy.We measured signs(size and sypmtoms) of mucositis by NCI-CTC scale and also we assessed the onset of the mucositis to describe the prevention efficacy of propolis.

Time frame: 9 month

Secondary Outcomes

hyposalivation scale

we use a scale for patients in 2 groups to assess effect of propolis maouth wash on subjective xerostomy and signs of candidiasis in patiants under radiotherapy

Time frame: 9 month

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.